William Powell and Myrna Loy starred in "The Thin Man" series of six films produced between 1934 and 1947. These entries exemplified the screwball touch. Nick and Nora Charles (Powell and Loy) were characters invented by Dashiell Hammett and "The Thin Man" movies had it all: plenty of wealth, some slapstick, misunderstandings, a lot of drinking, a strong female lead, and a good final resolution. They are fast paced, funny, sophisticated, and well worth watching.
Some of the Hollywood’s best were well suited for screwball comedy. They were all good looking, classy performers who weren’t afraid to take a pratfall or get a pie in the face. I have mentioned Cary Grant, Rosalind Russell, Carole Lombard, Gable and Colbert, and Powell and Loy. Others were also good such as: Melvyn Douglas ("Ninotchka" (1939) with Greta Garbo), Jean Arthur (The Ex-Mrs. Bradford (1936) with Powell), and Ginger Rogers ("Bachelor Mother" (1939) with David Niven).